HAPLOGROUP
X (MTDNA)
Haplogroup
X
Possible
time of origin ca. : 45,000–20,000 years ago
Ancestor : N
Descendants : X1, X2
Defining mutations : 73, 7028, 11719, 12705, 14766,
16189, 16223, 16278
Haplogroup
X is a human mitochondrial DNA (mtDNA) haplogroup. It is found in
America, Europe, Western Asia, North Africa, and the Horn of Africa.
mtDNA-based
chart of possible large human migrations
Haplogroup
X arose from haplogroup N, roughly 30,000 years ago (just prior
to or during the Last Glacial Maximum). It is in turn ancestral
to subclades X2 and X1, which arose ca. 20,000 and ca. 12,000 years
ago, respectively.
Distribution
:
Haplogroup X is found in approximately 7% of native Europeans, and
3% of all native North Americans.
Overall,
haplogroup X is found in around 2% of the population of Europe,
the Near East and North Africa. It is especially common, 14.3%,
among the natives of Bahariya Oasis (Western Desert, Egypt. The
X1 subclade is much less frequent, and is largely restricted to
North Africa, the Horn of Africa and the Near East.
Subclade
X2 appears to have undergone extensive population expansion and
dispersal around or soon after the Last Glacial Maximum, roughly
20,000 years ago. It is more strongly represented in the Near East,
the Caucasus, and Southern Europe and somewhat less strongly present
in the rest of Europe. The highest concentrations are found in Georgia
(8%), Orkney (Scotland) (7%), and amongst the Druze community in
Israel (27%). Subclades X2a and X2g are found in North America,
but are not present in native South Americans.
Archaeogenetics
:
Haplogroup X has been found in various other fossils that were analysed
for ancient DNA, including specimens associated with the Alföld
Linear Pottery (X2b-T226C, Garadna-Elkerülo út site
2, 1/1 or 100%), Linearbandkeramik (X2d1, Halberstadt-Sonntagsfeld,
1/22 or ~5%), and Iberia Chalcolithic (X2b, La Chabola de la Hechicera,
1/3 or 33%; X2b, El Sotillo, 1/3 or 33%; X2b, El Mirador Cave, 1/12
or ~8%) cultures. Haplogroup X has been found in ancient Egyptian
mummies excavated at the Abusir el-Meleq archaeological site in
Middle Egypt, which date from the late New Kingdom and Roman periods.
Fossils excavated at the Late Neolithic site of Kelif el Boroud
(Kehf el Baroud) in Morocco, which have been dated to around 5,000
years old, have also been found to carry the X2 subclade.
Druze
:
The greatest frequency of haplogroup X is observed in the Druze,
a minority population in Israel, Jordan, Lebanon, and Syria, as
much in X1 (16%) as in X2 (11%). The Druze also have much diversity
of X lineages. This pattern of heterogeneous parental origins is
consistent with Druze oral tradition. The Galilee Druze represent
a population isolate, so their combination of a high frequency and
diversity of X signifies a phylogenetic refugium, providing a sample
snapshot of the genetic landscape of the Near East prior to the
modern age.
North
America :
Haplogroup X is also one of the five haplogroups found in the indigenous
peoples of the Americas. (namely, X2a subclade).
Although
it occurs only at a frequency of about 3% for the total current
indigenous population of the Americas, it is a bigger haplogroup
in northern North America, where among the Algonquian peoples it
comprises up to 25% of mtDNA types. It is also present in lesser
percentages to the west and south of this area—among the Sioux
(15%), the Nuu-chah-nulth (11%–13%), the Navajo (7%), and
the Yakama (5%).
Unlike
the four main Native American mtDNA haplogroups (A, B, C, D), X
is not strongly associated with East Asia. The main occurrence of
X in Asia discovered so far is in the Altai people in Siberia.
One
theory of how the X Haplogroup ended up in North America is that
the people carrying it migrated from central Asia along with haplogroups
A, B, C, and D, from an ancestor from the Altai Region of Central
Asia. Two sequences of haplogroup X2 were sampled further east of
Altai among the Evenks of Central Siberia. These two sequences belong
to X2* and X2b. It is uncertain if they represent a remnant of the
migration of X2 through Siberia or a more recent input.
This
relative absence of haplogroup X2 in Asia is one of the major factors
used to support the Solutrean hypothesis during the early 2000s.
The Solutrean hypothesis postulates that haplogroup X reached North
America with a wave of European migration emerging from the Solutrean
culture, roughly 20,000 years ago. A stone-age culture in south-western
France and in Spain, by boat around the southern edge of the Arctic
ice pack. Since the later 2000s and during the 2010s, evidence has
turned against the Solutrean hypothesis, as no presence of mt-DNA
ancestral to X2a has been found in Europe or the Near East. New
World lineages X2a and X2g are not derived form the Old World lineages
X2b, X2c, X2d, X2e, and X2f, indicating an early origin of the New
World lineages "likely at the very beginning of their expansion
and spread from the Near East". A 2008 study came to the conclusion
that the presence of haplogroup X in the Americas does not support
migration from Solutrean-period Europe. The lineage of haplogroup
X in the Americas is not derived from a European subclade, but rather
represent an independent subclade, labelled X2a. The X2a subclade
has not been found in Eurasia, and has most likely arisen within
the early Paleo-Indian population, at roughly 13,000 years ago.
A basal variant of X2a was found in the Kennewick Man fossil (ca.
9,000 years ago).
Subclades
:
Tree :
This phylogenetic tree of haplogroup X subclades is based on the
paper by Mannis van Oven and Manfred Kayser Updated comprehensive
phylogenetic tree of global human mitochondrial DNA variation and
subsequent published research.
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X |
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X1 |
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X1a |
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X1a1 |
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X1b |
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X2 |
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X2a |
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X2a1 |
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X2a1a |
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X2a1b |
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X2a2 |
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X2b |
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X2b1 |
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X2b2 |
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X2b3 |
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X2b4 |
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X2c |
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X2c1 |
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X2c2 |
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X2d |
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X2e |
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X2e1 |
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X2e1a |
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X2e1a1 |
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X2e1a1a |
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X2e2 |
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X2e2a |
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X2f |
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X2g |
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X2h |
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Haplogroup
X diverged from Haplogroup N more than 30,000ybp. It further split
more than 20,000ybp into 2 main subgroups, X1 and X2. Haplogroup
X is found in Europe, the Near East, Central Asia, North Africa
and North America, and is believed to have migrated to the Americas
about 15,000 years ago, making up a very small component of the
Native American population (less than 3%). Bryan Sykes in his book
named this mtDNA haplogroup Xenia.
Haplogroup
X subclade X1 appears to be largely restricted to North Africa,
East Africa and the Near East. It is characterized by an HVR2 mutation
at 146. Haplogroup X1 is further divided into X1a and X1b.
Subclade
X2 is more widely distributed throughout Mediterranean Europe, the
Caucasus, the Near East and North America. Haplogroup X2 is divided
into further subgroups. X2a is found in a few geographically diverse
Native American populations, such as Navajo, Yakima and Ojibwa.
It is characterized by a HVR mutations at 200 and 16213. Recent
work has identified 2 sub branches of X2a. X2a1 in the Great Lakes
area, and X2a2 in the west. Another Native American subgroup X2g
has been identified as separate from X2a. X2b is the most geographically
diverse, covering Europe and the Near East. It is characterized
by an HVR2 mutation at 226. Recently an X2b1 subclade has been identified
in a group of Moroccans. X2c is characterized by an HVR1 mutation
at 255. X2d and X2e are characterized by mutations in the coding
region that can not be differentiated from other X2's without additional
mtDNA testing beyond HVR1 and HVR2. X2f is characterized by a HVR2
mutation at 257.
This
Motif table is used to estimate the subclades for Haplogroup X.
Exact identification requires markers in the mtDNA coding region
not covered by standard mtDNA HVR1 and HVR2 testing.
Haplogroup |
Particulars |
L3
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Regional
Concentration : Africa
HVR1
: 16223T
HVR2
: 73G
Coding
Region : 7028T, 10873T, 11719A, 12705T, 14766T |
N |
Regional
Concentration : Eurasia
HVR1
: L3
HVR2
: L3
Coding
Region : L3+10873C |
X |
Regional
Concentration : Eurasia, North Africa, North America
HVR1
: N+16189C, 16278T
HVR2
: N+153G
Coding
Region : N+6221C, 6371T, 13966G, 14470C |
X1 |
Regional
Concentration : North Africa, East Africa
HVR1
: X
HVR2
: X+146C
Coding
Region : ---
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X1a |
Regional
Concentration : North Africa
HVR1
: X1+16104T
HVR2
: X1
Coding
Region : ---
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X1c |
Regional
Concentration : North Africa
HVR1
: X1
HVR2
: X1
Coding
Region : 7337A, 9615C
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X2 |
Regional
Concentration : Eurasia, North America
HVR1
: X
HVR2
: X+195C
Coding
Region : 1719A
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X2a |
Regional
Concentration : Native American/First Peoples
HVR1
: X2+16213A
HVR2
: X2+200G
Coding
Region : 8913G, 12397G, 14502C
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X2a1 |
Regional
Concentration : North American Great Lakes / Plains
HVR1
: X2a+16093C
HVR2
: X2a+143A
Coding
Region : 3552C
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X2a1a |
Regional
Concentration : Sioux
HVR1
: X2a1+16357
HVR2
: X2a1
Coding
Region : 6113G
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X2a1b |
Regional
Concentration : Ojibwa
HVR1
: X2a1
HVR2
: X2a1
Coding
Region : 8422G
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X2a2 |
Regional
Concentration : Nuu-Chah-Nulth, Na-Dene-Navaho, Yakima
HVR1
: X2a+16254C
HVR2
: X2a+225C
Coding
Region : ---
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X2b |
Regional
Concentration : Eurasia, Orkney, Druze
HVR1
: X2
HVR2
: X2+225A+226C
Coding
Region : 8393T, 15927A
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X2b1 |
Regional
Concentration : Kazakhstan
HVR1
: X2b+16248T
HVR2
: X2b
Coding
Region : 8814T
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X2b2 |
Regional
Concentration : Morocco
HVR1
: X2b
HVR2
: X2b
Coding
Region : 4722, 7400A, 11908
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X2b3 |
Regional
Concentration : ---
HVR1
: X2b
HVR2
: X2b
Coding
Region : 8269, 14818C
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X2b4 |
Regional
Concentration : Levant, UK, France, Central Europe
HVR1
: X2b
HVR2
: X2b
Coding
Region : 3705
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X2b5 |
Regional
Concentration : Scandanavia
HVR1
: X2b
HVR2
: X2b+188G
Coding
Region : 12477C
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X2c |
Regional
Concentration : Eurasia
HVR1
: X2+16255A
HVR2
: X2
Coding
Region : ---
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X2c1 |
Regional
Concentration : ---
HVR1
: X2
HVR2
: X2
Coding
Region : 8705C
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X2c1a |
Regional
Concentration : Germanic countries, Ukraine, Finland
HVR1
: X2+16108
HVR2
: X2
Coding
Region : ---
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X2d |
Regional
Concentration : Eurasia
HVR1
: X2
HVR2
: X2
Coding
Region : 6791G, 8503C
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X2e |
Regional
Concentration : Georgia, Kyrgyz, Altai
HVR1
: X2
HVR2
: X2
Coding
Region : 15310C
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X2e1 |
Regional
Concentration : ---
HVR1
: X2+16189A
HVR2
: X2
Coding
Region : ---
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X2e1a |
Regional
Concentration : ---
HVR1
: X2e1
HVR2
: X2
Coding
Region : 9380
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X2e2 |
Regional
Concentration : Turkey, UK
HVR1
: X2
HVR2
: X2
Coding
Region : 12084
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X2e2a |
Regional
Concentration : Levant, Yemen, Altail
HVR1
: X2
HVR2
: X2
Coding
Region : 3948
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X2f |
Regional
Concentration : South Caucasus
HVR1
: X2
HVR2
: X2+257G
Coding
Region : ---
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X2g |
Regional
Concentration : Ojibwa
HVR1
: X2+
HVR2
: X2+?
Coding
Region : ---
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One
theory of how the X Haplogroup ended up in North America is they
migrated from central Asia along with the A,B,C, and D Haplogroups.
It is interesting that no Haplogroup X traces have been found in
Siberia. The nearest X Haplotypes have been found is the Altai region
of central Asia. This theory is supported by yDNA studies [Zegura.]
Schurr
postulates that Haplogroup X arrived in North America via the central
corridor which became free of ice about 12500 ybp.
Another
theory, The Solutrean Hypothesis, is that the there was a early
pre-Clovis Atlantic migration route in addition to the Asian Bering
Straight land bridge as shown on the following map :
Other
more imaginitive theories include :
The
Mormon hypothesis, which states the Haplogroup X in North American
could be the result of descendants of Lehi and Sariah as mentioned
in the Book of Mormon.
The
Neanderthal Hypothesis. That Haplogroup X mtDNA is descended from
the Homo Sapiens Neanderthalis. While there are some X motif markers
present in some Neanderthal mtDNA samples, there are also many more
differences.
And
finally, the Atlantis hypothesis, Where Haplogroup X is identified
with the remenants of the Atlantean civilization.
Source
:
https://en.wikipedia.org/
wiki/Haplogroup_X_(mtDNA)
https://www.familytreedna.com/
groups/x/about/background